Journal of IiMER May 2025 Mette Olufsen North Carolina State University, USA BRMEC14: Models Extracting the Sympathetic/Parasympathetic Tone Mette Olufsen is a distinguished professor from North Carolina State University, USA, who brings a unique perspective to the session with her expertise in mathematical modelling and physiology. Her work focuses on developing quantitative models to understand complex biological systems, including the autonomic nervous system. Professor Olufsen's presentation will highlight how mathematical modelling can be applied to unravel the intricacies of orthostatic intolerance in ME, providing a novel approach to research and treatment. Her participation in the colloquium exemplifies the interdisciplinary nature of #BRMEC14, fostering innovative solutions to complex medical challenges. Professor Olufsen will discuss mathematical and computational models that assess the balance between sympathetic and parasympathetic nervous system activity. These models can help objectively evaluate autonomic dysfunction in ME/CFS. Branislav Milovanović Institute for Cardiovascular Diseases-Dedinje, Serbia BRMEC14: Assessment of Autonomic Nervous System Function in Patients with ME and PostCOVID-19 Syndrome Presenting with Recurrent Syncope: Neurocardiological Approach Professor Branislav Milovanović is a full professor of Internal Medicine – Cardiology at the Faculty of Medicine in Belgrade and Chief of the Neurocardiologist Laboratory at the Institute for Cardiovascular Diseases-Dedinje in Serbia. He is also a professor at the Medical Faculty in Saransk, Russia, and an active member of the European Academy of Sciences and Arts. Professor Milovanović is a pioneer of neurocardiology in Serbia, having introduced clinical assessment protocols for autonomic nervous system function and organized key international symposia in the field. His expertise includes noninvasive electrocardiology, cardiovascular risk assessment, autonomic nervous system dysfunction, chronic fatigue syndrome (ME/CFS), syncope, and post-COVID-19 syndrome. At BRMEC14, Professor Milovanović will present a neurocardiological approach to assessing autonomic nervous system function in patients with ME/CFS and post-COVID-19 syndrome who experience recurrent syncope (fainting). His presentation will focus on how autonomic dysfunction contributes to these symptoms, using cardiovascular autonomic reflex tests and heart rate variability analysis to improve diagnosis and treatment strategies. This work highlights the importance of cardiovascular autonomic neuropathy in understanding and managing both ME/CFS and post-COVID conditions, offering a comprehensive clinical perspective on recurrent fainting in these patient groups. Invest in ME Research Page 26 of 43
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