Journal of IiMER May 2025 Artur Fedorowski Karolinska Institutet, Stockholm, Sweden BRMEC14: Mechanisms Underlying Cardiovascular Autonomic Dysfunction, POTS and IST in Long COVID and ME Artur Fedorowski from the Karolinska Institutet in Stockholm, Sweden, will share his extensive knowledge on autonomic physiology and its dysregulation in ME. Dr. Federowski's work has significantly contributed to our understanding of the autonomic nervous system's role in chronic illnesses. His presentation at #BRMEC14 will explore the intricate mechanisms underlying autonomic dysfunction in ME patients, offering potential avenues for diagnostic and therapeutic interventions. Dr. Federowski's participation underscores the colloquium's commitment to fostering international collaboration and advancing ME research. Professor Fedorowski will present research on the mechanisms of postural orthostatic tachycardia syndrome (POTS) and inappropriate sinus tachycardia (IST), syndromes frequently seen in both ME/CFS and Long COVID. His work explores autonomic nervous system regulation and its disruption in these conditions. Peter Novak Brigham and Women's Hospital, Harvard Medical School, USA BRMEC14: Orthostatic Intolerance and its Management-Strategies for Clinicians and Researchers Dr Peter Novak is a neurologist and autonomic specialist at Brigham and Women’s Hospital and Harvard Medical School, with extensive expertise in orthostatic intolerance and autonomic disorders. His research has significantly advanced understanding of conditions such as postural orthostatic tachycardia syndrome (POTS) and hypocapnic cerebral hypoperfusion (HYCH), both of which frequently overlap with ME/CFS. Dr Novak’s work employs comprehensive autonomic testing, including tilt-table tests, cerebral blood flow velocity monitoring, and cardiopulmonary exercise testing, to characterise the physiological mechanisms underlying orthostatic intolerance. He has identified biomarkers such as hypocapnia and cerebral hypoperfusion that help distinguish subtypes of orthostatic intolerance and guide diagnosis and treatment. At BRMEC14, Dr Novak will present practical strategies for clinicians and researchers on diagnosing and managing orthostatic intolerance in ME/CFS, drawing on his extensive clinical experience and research into autonomic dysfunction. His insights aim to improve patient care and inform targeted therapeutic approaches for this complex and often debilitating aspect of ME/CFS.intolerance in ME/CFS, based on his extensive experience in autonomic testing and patient care. Invest in ME Research Page 25 of 43
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