Journal of IiMER May 2025 extracellular vesicles-tiny membrane-bound packages that may carry microbial components and could serve as diagnostic or therapeutic marker targets for ME/CFS. Her path to researching the role of viruses in ME/CFS is grounded in her extensive experience in molecular virology. She says, “My expertise spans from identifying antiviral compounds to understanding how viruses develop resistance.” Her work has deepened her interest in how certain viruses evade immune responses and contribute to long-term health issues. Looking ahead, Krishani hopes to develop future diagnostics for ME/CFS. “Longer term, I want to understand ME/CFS pathology and disease progression. By identifying potential causes and underlying mechanisms, I hope to contribute to the development of better diagnostic tools for early and accurate detection. Ultimately, my goal is to explore effective and targeted treatments to improve patient outcomes and quality of life.” She stresses the complexity of ME/CFS: “Because there is no one known cause for ME/CFS and it’s a complex condition with interconnected biological mechanisms, we need to be cautious when interpreting data on potential links between symptoms, immune dysfunction and microbes. A simplistic approach could overlook crucial factors, so a comprehensive, interdisciplinary perspective is essential when studying ME/CFS.” Krishani concludes, “At the end of the day, it’s not just about scientific rigour but about raising awareness-not only to improve research and treatment options but also to foster empathy and respect for those living with this invisible illness. By understanding ME/CFS, we can help create a more supportive and inclusive world for those affected.” She expresses her gratitude: “I am very grateful to the Invest in ME Research charity and the LunaNova fellowship for their support with funding for the research I am conducting.” Further information: https://tinyurl.com/Quadram-Krishani Light ME Up: Red Light Therapy Study for ME at Quadram Institute The Quadram Institute, in partnership with the University of East Anglia (UEA) and with support from Invest in ME Research, is conducting a feasibility study called Light ME Up to explore the potential of red light therapy for ME. Launched in 2024, this study investigates whether photobiomodulation can help relieve symptoms of ME. By targeting mitochondrial dysfunction, thought to contribute to ME’s debilitating fatigue, the study aims to open new avenues for treatment. Light ME Up was set up initially to involve ten participants with ME, recruited through the charity’s network. This has now been expanded. The lamp is designed to stimulate mitochondrial function and Invest in ME Research Page 9 of 43
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