ISBN : 978-93-85073-24-3 polymer is most suitable for development of a micelle based formulation for a specific drug. The ultimate goal of the test is to generate information that can provide an insight into the mechanism by which the drug is being released from the dosage form and provide data to facilitate the rational and rapid research, optimization and development of a modified release dosage form. The drug releases based on polymeric micelles that are currently in clinical trial evaluation represent significant milestones in this area. These advancements encourage further efforts in the design and development of polymer based nanocarriers as drug delivery vehicles. The interdisciplinary efforts in this field bringing together polymer chemist, pharmaceutical and medical scientists will continue to move the research forward to create new and improved technologies that are tailor made to suit the delivery of challenging molecules. It is only a matter of time before a formulation based on polymeric micelles is approved for treatment. The technological approach is a non-invasive method of drug delivery to the CNS. It is based on the use of nanosystems (colloidal carriers), which could be lipidbased (liposomes or solid lipid nanoparticles) or polymer-based nanoparticles. Nanotechnological approaches to neurodevelopmental, neurological and neuropsychiatric disorders include (a) using nanoparticles or nanocarriers to deliver drug or gene therapies, (b) using nanotechnology to reconstruct, reinforce, and/or stabilize the cytoskeletal matrix, (c) using nanofabrication methods to make biohybrid transport devices, and (d) coating electrodes with nanoparticles. Thus, this field of research represents one of the most stimulating challenges for the scientific world, as a result of the limited number of therapeutics capable of reaching the most ‘secret and sacred’ system of the body, the CNS. Nanotechnology is a multi disciplinary field, convergence of basic sciences and applied disciplines like biophysics, molecular biology, and bio engineering. Size reduction is a fundamental unit operation having important application in pharmacy. Major advantages of nano sizing include - (a) Increase surface (b) Enhanced solubility (c) Increase rate of dissolution and oral bio availability (d) Rapid onset of action (e) Less amount of dose required in the field of pharmacy. For applications to medicine and physiology these materials and devices can be designed to interact with a 15
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