ISBN : 978-93-85073-24-3 Micellization is a critical phenomenon when considering detergent applications. Each detergents can be characterized by its critical micelle concentration (CMC); the concentration of detergents above which monomers self-assemble into non-covalent aggregates (called micelles) [152-153]. The CMC actually does not occur at a single concentration, but rather, over a narrow concentration range. When the total detergent concentration is below the CMC, detergent monomers are free in bulk solution. However, as more detergent is added above the CMC, all additional detergent monomers will go into micelles. It is important to note that when the total detergents concentration is greater than the CMC, there is a monomeric detergent concentration equal to the CMC and a micellar detergent concentration equal to: (total detergent concentration)-CMC. The CMC can be determined by a variety of methods including surface tension measurements and conductivity measurements [154-155]. Micelles made of nonionic surfactants are widely used as adjuvants and drug carrier system in many areas of pharmaceutical technology and controlled drug delivery [156-161]. Significance of works In the last decade, an emerging interest has been growing towards brain drug targeting where issues have been widely discussed [162-169]. The increasing awareness of the lack of rational and common efforts among different and complementary research areas has pointed out the need for a deeper understanding and a closer collaboration among diverse research experts of the field [170]. The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. For decades pharmaceutical sciences have been using nanoparticles to reduce toxicity and side effects of drugs. The book has explored the most recent intellectual property on polymer-based nanotechnological strategies for the design of optimal drug delivery devices. This is an effervescing area, with large investment volumes being poured by both public and private sectors. Most of the novelties still remain as experimental enterprises and are dealing with regulatory agencies to get approval. A key feature is to understand and internalize that due to the multidisciplinary nature of this area convergence of different professionals is demanded to bring a product to the market. In this book, we found that calculation and comparison of partial solubility parameters of polymer and drug could be used as a reliable means to predict which 14
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