JOURNAL OF IIMER May 2026 Invest in ME Research has always maintained a clear focus: directing funding towards rigorous biomedical research with real potential, building a sustainable research base, and driving meaningful progress. The fellowships at Norwich Research Park are a direct expression of that commitment. Further information on Dr Seton: https://quadram.ac.uk/people/katherine-seton/ Further information on Dr Perera: https://tinyurl.com/Quadram-Krishani Light ME Up – Exploring Red Light Therapy for ME In April 2024, Dr Katharine Seton, PhD – the Ian Gibson Fellow funded by Invest in ME Research – began a pilot study looking at whether red light therapy could be helpful for people with ME. Red light therapy is already an approved treatment (by the FDA) for conditions such as chronic pain, wound healing, and hair regrowth. However, it has not previously been formally tested in people with ME/CFS. Early research in other conditions suggests it may help improve energy levels, reduce pain, and support blood circulation. These are all areas that can be challenging for people with ME, so it made sense to explore whether this therapy might offer some benefit. Red light is absorbed by the mitochondria – often described as the “batteries” inside our cells – where it may help increase energy production. Research also suggests that timing matters, as the therapy appears to work best in the morning, in line with the body’s internal (circadian) clock, particularly between 9am and 11am. Importantly, the device used in this study was a targeted single-wavelength red light specifically designed for research purposes. This is difference from many commercially available products, which usually emit a broad spectrum of light. We would strongly advise patients not to purchase or use red light devices based on this early-stage research. How the study worked Over a 12-month period, 26 people with ME from across the UK took part in this 9-week study. Importantly, the study was carried out entirely from home, so participants could take part in a way that suited their needs. This approach also made it possible for people who are more severely affected by ME to be involved in research. Before starting the therapy, participants completed a set of assessments to understand their symptoms and daily functioning. These included: • A questionnaire about their ability to carry out everyday activities (FUNCAP27) • Online cognitive (thinking and memory) tests • Wearing a wrist activity monitor for seven days • Keeping a sleep diary for seven days Once these were completed, participants were sent a red light lamp to use at home. Invest in ME Research Page 7 of 35
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