Journal of IiMER May 2025 The research supports the view that immune-metabolic crosstalk is central to ME pathology, aligning with the metabolic trap hypothesis and highlighting how disruptions in immune cell metabolism may perpetuate ME symptoms. Demonstrating itaconate’s anti-inflammatory effects and its modulation of immune signalling, the study points to new therapeutic possibilities for managing chronic immune activation and inflammation in ME. At BRMEC14, Drs Artyomov and Paulenda will present their systems biology approach, which integrates computational modelling, multi-omics data, and redox signalling. Their work exemplifies the synergy between systems biology, immunology, and redox signalling, and supports the colloquium’s aim of translating molecular discoveries into clinical solutions. Their participation will enrich discussions on how metabolic rewiring and redox imbalances drive immune dysfunction in ME, advancing collaborative research in this complex field. BRMEC14 Session: Immune System Primary and Secondary Session Chair: Eva Untersmayr-Elsenhuber, Medical University of Vienna, Austria Professor Untersmayr-Elsenhuber, a leader in immunology and ME/CFS research, will guide the session, highlighting recent advances in understanding immune dysfunction and its role in ME/CFS pathogenesis. Muzlifah Haniffa, Wellcome Sanger Institute, UK BRMEC14: Impact of Viral (SARS-CoV-2) Infections on Immune Cells and Insights for ME Prof Haniffa is currently serving as the Interim Head of Cellular Genetics and Senior Group Leader at the Wellcome Sanger Institute and is a renowned immunologist and dermatologist. Her talk promises to offer valuable perspectives on the immunological aspects of ME. Prof Haniffa's research focuses on applying cutting-edge genomic technologies to unravel complex biological processes. As a key contributor to the Human Cell Atlas initiative, her work in mapping human cell types and states across tissues may offer new perspectives on the multi-system nature of ME. Her collaborative approach and interdisciplinary expertise make her a valuable addition to the ongoing efforts to understand and address this complex condition. Prof Haniffa is a pioneer in applying single-cell genomics technologies to understand tissue homeostasis, immunity, and disease pathogenesis. Her expertise in decoding the development and functional maturation of the human immune system is particularly relevant to ME research, as immune dysfunction is a key area of investigation in the field. This could provide valuable insights into the immunological aspects of ME, potentially shedding light on the disease's underlying mechanisms. The presentation will be part of the Immunology session, moderated by EMERG member Associate Professor Eva Untersmayr-Elsenhuber of the Medical University of Vienna, Austria. Professor Haniffa's research on the impact of SARS-CoV-2 on immune cells could provide crucial insights into ME, Page 22 of 43 Invest in ME Research
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