Journal of IiMER May 2025 BRMEC14 Session: Systems Biology Approaches to Study Infections in Complex Diseases Session Chair: Tamas Korcsmaros (Imperial College London) Tamas Korcsmaros is a distinguished researcher and lecturer at Imperial College London, specialising in systems biology and network medicine. His work focuses on understanding the complex interactions within biological systems to uncover the mechanisms underlying diseases. With a strong background in bioinformatics and computational biology, he has made significant contributions to the field, particularly in network analysis and multi-omics data integration. Dr Korcsmaros is known for his innovative approaches to deciphering the intricate web of molecular interactions that influence health and disease. His research aims to bridge the gap between basic science and clinical applications, seeking to identify new therapeutic targets and strategies for treating complex conditions. At BRMEC14, Dr Korcsmaros will moderate the session on systems biology, bringing his expertise and insights to facilitate discussions on the latest advancements and future directions in the field. This session underscores the importance of integrative and collaborative research efforts in advancing our understanding of ME. Aurelien Dugourd (Saez-Rodriguez Group, EMBL-EBI, UK) BRMEC14: Application of Systems Biology to Understand Complex Chronic Diseases Aurelien Dugourd is a Staff Scientist in the Saez-Rodriguez Group at the European Bioinformatics Institute (EMBL-EBI), UK, specialising in computational biology and multiomics data integration. His work focuses on developing methods to extract mechanistic insights from genomics, proteomics, and metabolomics data, with the goal of understanding disease processes and supporting therapeutic innovation. Dr Dugourd’s research is particularly relevant to complex chronic diseases such as ME/CFS, where intricate molecular interactions contribute to disease heterogeneity. The Saez-Rodriguez Group, led by Julio Saez-Rodriguez, is renowned for its expertise in computational biology and systems medicine. The group's research integrates computational modelling with experimental data to unravel the molecular mechanisms underlying complex diseases. Their work aims to translate intricate biological data into actionable insights, driving the development of new therapeutic strategies. At BRMEC14, Aurelien will share his insights and the group's latest advancements in systems biology. His presentation will highlight how integrating multi-omics data can provide a comprehensive understanding of disease pathogenesis, particularly in ME. His participation underscores the importance of interdisciplinary research and collaborative efforts in advancing our knowledge of this complex condition. Invest in ME Research Page 14 of 43
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