Journal of IiMER generation by oxidative phosphorylation and excessive lactate generation upon exertion. Professor Warren Tate Group Leader, Biochemistry Department, School of Biomedical Sciences, University of Otago, New Zealand Professor Warren Tate from University of Otago in New Zealand - is an internationally respected biochemist, winner of the Royal Society of New Zealand's top science honour - the 2010 Rutherford Medal, and was also named a Companion of the New Zealand Order of Merit. His honour citation noted that Professor Tate was a molecular biologist, whose research had "revolutionised understanding" of how proteins were synthesised in living cells. His research had shown how proteins contributed to memory formation and neurological disease, and had important implications for HIV, Alzheimer's and chronic fatigue syndrome. Professor Tate is a Fellow of the Royal Society of New Zealand and of the New Zealand Institute of Chemistry. He has been a Fellow of the Alexander von Humboldt Foundation of Germany, and an International Research Scholar of the Howard Hughes Medical Institute of the United States. Abstract: Intense molecular study of well characterised patients to understand the acute phase, perpetuation, and relapse/recovery cycles in ME/CFS Warren P. Tate, Department of Biochemistry, School of Biomedical Sciences, Division of Health Sciences, University of Otago, PO Box 56 Dunedin, New Zealand From the moment of my first exposure over 20 years ago to ME/CFS as the illness afflicting a vibrant young teenage daughter, I have puzzled over what physiological ‘control centre’ could mediate such a range of dramatic body-wide responses. As my daughter’s illness progressed into a long-term condition this question evolved into what is preventing recovery and not allowing perpetuation of ME/CFS, and then what physiological changes are occurring during the frequent relapses experienced throughout the chronic phase of the disease. On a brighter note a significant improvement occurred during a pregnancy –why did that happen? Resolution of these unresolved yet important questions would give significant benefit to patients, as well as being of marked scientific interest. As research into ME/CFS has progressed in recent decades there has been a pressing need to collect comprehensive molecular data on well-characterised patients so a framework can be created for evidence-based approaches to the disease. This would have relevance for developing a diagnostic test, and to set directions towards better patient management and therapies. We have studied purified www.investinme.org Page 77 of 82

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