Journal of IiME Volume 7 Issue 1 Infectious Diseases at Stanford University and its affiliated hospitals. Following his clinical training, he remained at Stanford with NIH funding to engage in post-doctoral research in microbiology, immunology and bioinformatics with Dr. Ellen Jo Baron and Dr. Stanley Falkow, where he explored host-response profiles in severely ill patients. Together with Dr. José Montoya, he was instrumental in the conception, design, and execution of the EVOLVE study - a placebo-controlled, double-blind study of a subset of chronic fatigue syndrome patients with evidence of viral infection. Dr. Kogelnik worked with Dr. Atul Butte in translational informatics to determine patterns that indicated a high risk for adverse events in paediatric patients at Lucille Packard Children's Hospital. He is the Medical Director of the Open Medicine Clinic - a communitybased research clinic focussed on chronic infectious diseases, neuroimmune disease, and immunology. Dr. Kogelnik has published numerous scientific papers and book chapters, is an Editor of Computers in Medicine and Biology, and is a Consulting Assistant Professor at Stanford University. With the Open Medicine Institute, he has led the formation of CFS and Lyme Registries and Biobanks as well as creating an infrastructure for providers to collect better data and implement clinical trials across a network of sites. Abstract: Not available at time of printing – but will be available on Invest in ME web site. The Role of the Brain and ME Rakib Rayhan (May 2013) Gulf War Illness (GWI), and Fibromyalgia (FM). Understanding pain perception, autonomic and cognitive dysfunction in relation to abnormal functional and structural changes within the brain in GWI has been Mr. Rayhan’s specific focus for the 2 past years. He has discovered that white matter alterations in the right inferior-frontal occipital fasciculus are strongly associated with the severity and perception of pain and fatigue. In addition, he has identified two unique phenotypes based upon autonomic and hyperalgesic changes in response to an exercisechallenge. Changes in symptoms were associated with distinct patterns in working memory cognitive networks and discrete regions of brain atrophy. These recent discoveries have substantiated GWI as a central nervous system disorder. He is actively engaged in further pursuing a systems biology approach to the neuroimaging research by examining genomics, proteomics and metabolomics. His desire is to identify potential biomarkers that provide objective support to disease criteria and that are then translated into new and affordable therapies leading to a better quality of life for patients. Abstract Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling and complex disease state characterized by profound fatigue, chronic pain, autonomic dysregulation, headaches, sleep disturbances, cognitive dysfunction, endocrine, immune and exertional exhaustion. ME/CFS is a part of a larger group of idiopathic interoceptive and nociceptive illnesses such as Gulf War Illness (GWI), Irritable bowel syndrome (IBS), migraines and Fibromyalgia (FM). Such syndromes greatly impair quality of life and have a high economic burden. Despite considerable research ME/CFS, GWI, and FM are diagnoses of exclusion that is further complicated by symptom severity, subphenotypes and a lack of quantifiable objective biomarkers. Rakib Rayhan works with Dr James Baraniuk at Georgetown University, Washington, and is deeply interested in symptomatic development and chronification of pain and fatigue in idiopathic illnesses such as Myalgic Encephalomyelitis (ME), Invest in ME (Charity Nr. 1114035) Exercise based paradigms have been useful models to show dynamic symptom alterations in CFS/ME and FM. This raised the question of whether increased susceptibility to stressor paradigms can elucidate objective evidence for the entire symptom complex. Utilizing both exercise provocation and functional magnetic resonance imaging (fMRI) technology, Dr. James Baraniuk has developed a novel paradigm to characterize the causality between inappropriate stressor response and www.investinme.org Page 25 of 36
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