Journal of IiME Volume 1 Issue 2 www.investinme.org Visible and near-infrared (Vis-NIR) spectroscopy: Introduction and Perspectives for Diagnosis of CFS (continued) Fig. 4. SIMCA analysis of Vis-NIR spectra of serum samples for CFS diagnosis (A-B) Vis-NIR spectra of serum samples from healthy donors (Blue) and CFS patients (Red) were subjected to SIMCA. Coomans plots show distances to model of healthy donors versus CFS patients to establish a SIMCA model (A). Discriminating power shows the importance of each wavelength for distinguishing healthy donors from CFS patients (B). (C) Masked samples, which were not used for development of the model, were subjected to SIMCA. Coomans plots show distances to model of healthy donors versus CFS patients. Modified from Fig. 2 in Sakudo et al. [86] with permission from Elsevier. References [1] K. Fukuda, S.E. Straus, I. Hickie, M.C. Sharpe, J.G. Dobbins, and A. Komaroff, The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 121 (1994) 953-9. [2] L.A. Jason, J.A. Richman, A.W. Rademaker, K.M. Jordan, A.V. Plioplys, R.R. Taylor, W. McCready, C.F. Huang, and S. Plioplys, A community-based study of chronic fatigue syndrome. Arch Intern Med 159 (1999) 2129-37. [3] H. Kuratsune, Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria. Nippon Rinsho 65 (2007) 983-90. Invest in ME Charity Nr 1114035 [4] K.J. Reynolds, S.D. Vernon, E. Bouchery, and W.C. Reeves, The economic impact of chronic fatigue syndrome. Cost Eff Resour Alloc 2 (2004) 4. [5] M. Reyes, R. Nisenbaum, D.C. Hoaglin, E.R. Unger, C. Emmons, B. Randall, J.A. Stewart, S. Abbey, J.F. Jones, N. Gantz, S. Minden, and W.C. Reeves, Prevalence and incidence of chronic fatigue syndrome in Wichita, Kansas. Arch Intern Med 163 (2003) 1530-6. [6] S.D. Vernon, T. Whistler, E. Aslakson, M. Rajeevan, and W.C. Reeves, Challenges for molecular profiling of chronic fatigue syndrome. Pharmacogenomics 7 (2006) 211-8. (continued on page 15) Page 14/72

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