ISBN : 978-93-85073-24-3 • Nanocarriers holds promise to deliver biotech drugs over various anatomic extremities of body such as blood brain barrier, branching pathways of the pulmonary system and the tight epithelia junctions of the skin etc. • Nanocarriers better penetrate tumors due to their leaky constitution, containing pores ranging from 100-1000 nm in diameter. Fig 1.1: Multidisciplinary Functions of Nanocarriers Anti-Depressants Depression is estimated to affect nearly 340 million people worldwide and 18 million people in the United States at any given time [100]. A number of studies have documented the enormous impact of this debilitating condition on both patients and the health care system [101-104]. In the primary care setting, diagnosis of a depressive disorder is complicated by the fact that depressed patients frequently present with a combination of emotional and physical symptoms [105-109]. The importance of physical symptoms was highlighted by a recent international study which found that almost 70% of depressed patients reported physical symptoms as the only reason for visiting their physician [110]. Physical symptoms often associated with depression include headaches, back pain, gastrointestinal disturbance (e.g., irritable bowel syndrome), and generalized aches and pains [111]. 5
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