THE REVERE ADVOCATE – FRIDAY, MAY 30, 2025 Page 7 Revere’s Prominent and Preeminent, World-Class, Medical Doctors and Medical Scientists By John J. Henry N ow that high school and college graduation season is upon us, looking back over the years at what a number of former students and graduates of Revere’s schools have achieved in higher education and in their chosen professions and career, as they moved on from Revere, has proved to be very interesting. Beginning in the 1950s and extending into the 1980s, five world-class doctors were raised in Revere and received their early education in Revere schools. The question raised: Is their stature as world-class medical doctors and scientists an expression of nature or nurture? The nature versus nurture debate is about which part of a person’s intellect is more important, their inherited qualities, which include genes, or their personal family and environmental life experiences and infl uences relative to the way that they were raised. While the philosophical debate has gone on for thousands of years, whatever the case may be, fi ve prominent and preeminent, world-class doctors and medical scientists had their beginnings and received their early education in Revere. Here are their stories and medical accomplishments and achievements: Dr. Charles A. Dinarello ceiving his Doctor of Medicine degree from Yale in 1969. Following graduation from Yale, he did his clinical training at Massachusetts General Hospital, and until 1996 he was a staff physician at New England Medical Center, as well as a professor of Medicine at Tufts University. Dr. Dinarello also served as a senior investigator at the National Institute of Health in Bethesda, Maryland. Dr. Dinarello has also served on the editorial boards of several scientifi c journals and has published over 1,000 original research articles and 250 reviews and book chapters on cytokines, particularly on Interleukin-1 and related cytokines. Cytokines are small proteins that serve as chemical messengers in the immune system of the body to help cells communicate with each other, the socalled “software” that runs the immune system to grow, behave and interact in specific ways, to fi ght allergens, pathogens and harmful substances — fi ghting off diseases and infection — and may be the key to understanding and treating autoimmune disorders. Dr. Dinarello’s pioneering research work focuses on the development of cytokines targeting biological therapies for the treatment of infl ammatory diseases in humans, such as rheumatoid arthritis, gout, Parkinson’s disease and the treatment of tumor progression in cancer. Dr. Dinarello is considered one of the founding fathers of cytokines, having purified and been the fi rst to identify Interleukin-1, a protein that helps the body’s immune system fi ght infections. Dr. Dinarello has trained over 50 medical investigators, many of whom are recognized as experts in their fi elds of medicine. The Institute for Science Information has listed Dr. Dinarello as the world’s fourth most cited scientist during the 20 years from 1983-2002. In 1998, Dr. Dinarello was D r. Charles A. Dinarello graduated from Revere High School in 1961; he went on to study at Boston University, graduating in 1965 (magna cum laude). After graduation he entered Yale University, reelected to the United States National Academy of Sciences, and in 2011 he became a foreign member of the Royal Netherlands Academy of Arts and Sciences. He is a member of the Board of Governors of the Weizmann Institute (Israel) and Ben-Gurion University (Israel). He is also the former Vice President of the American Society of Clinical Investigation, and he also served as President of the International Cytokine Society. He has received honorary degrees from the University of Marseille (France), the Weizmann Institute of Science (Israel), the University of Frankfurt (Germany), Roosevelt University (USA), Albany Medical College (USA), Radbound University (Netherlands) and Trinity College (Ireland). For his contributions to the fi eld of Cytokines and medicine, Dr. Dinarello received the Squibb Award (USA), the Ernest Jung Prize in Medicine (Germany), the Chirone Prize (Italian National Academy of Medicine), Carol Nachman Prize (Germany), Sheikh Hamdan bin Rashid al Madktoum Award (United REVERE’S | SEE Page 8
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