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Journal of IiMER biomarkers for autism in a prospective study in Norway, the Autism Birth Cohort (ABC). She established that there was no association between intestinal measles virus transcripts and autism, and, with Brent Williams and W. Ian Lipkin at CII, has found altered expression of genes relating to carbohydrate metabolism and inflammatory pathways and differences in the bacteria harboured in the intestines of children with autism. She also leads projects examining the influence of immune molecules on brain development and function and their role in the genesis of schizophrenia, major depression, and cardiovascular disease comorbidity in adults, and directs the Chronic Fatigue initiative Pathogen Discovery and Pathogenesis Project at CII. In 2004, Dr. Hornig presented to the Institute of Medicine Immunization Safety Review Committee and testified twice before congressional subcommittees regarding the role of infections and toxins in autism pathogenesis. Her work in ME/CFS is establishing immune profiles and helping to identify pathogens that may be linked to disease. Abstract: Not present at time of going to press. Professor Olav Mella Department Director, Oncology, Haukeland University Hospital, University of Bergen, Norway Professor Mella has performed clinical trials to test the benefit of B-cell depletion therapy using Rituximab in ME/CFS patients. Professor Olav Mella of Haukeland University Hospital in Bergen, Norway began his investigation of Rituximab’s effects on CFS after treating several Hodgkin’s Lymphoma patients who had long standing cases of CFS prior to developing cancer. Professor Mella and Dr Fluge have published a paper "Benefit from BLymphocyte Depletion Using the Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study" Abstract: Status of the Norwegian drug intervention studies on ME (RituxME and CycloME) Olav Mella: for the Norwegian cooperative trial group at Haukeland University Hospital (Bergen), Oslo University Hospital, Telemark Central Hospital – Notodden, St. Olav Hospital (Trondheim) and University Hospital of Northern Norway (Tromsø) Haukeland University Hospital has previously performed studies indicating that immune manipulation by B-lymphocyte depletion may result in symptom improvement in a subgroup of patients with ME, pointing at defects in immune function to be important factors in the disease mechanisms. Following www.investinme.org Page 74 of 82

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